Does anyone know a good broad book on physiological barriers to human spaceflight which focuses on the science and engineering not on arguing against crewed spacetravel?

The one by the Weinersmiths is supposed to be snarky commedy, I don't remember Mary Roach being interested in things like degenerative eye problems or filtering water or keeping moon dust out of the habitat. Digging up individual papers without an overview feels like a deep and confusing rabbit hole. #space #boostsAppreciated