In today's episode of poor uses of ARIA, when you link directly to an issue comment (not just the issue itself) in GitHub, you get this (simplified):
<a aria-label="Issue #904" href="github.com/nvaccess/nvda/issue…">#904 (comment)</a>
So a screen reader user gets "issue #904" while a sighted user sees "#904 (comment)". So the fact that it is a link to a comment is lost to the screen reader user. Seriously, people!
#accessibility
in reply to Sukil Etxenike

@sukiletxe I know right? The only thing I can think is that there might be an icon visually which indicates whether it's a pull request or an issue. Maybe someone complained or they just decided that they should expose that information, so they did it in the aria-label... without considering the loss of other contextual information provided by the text.