@WestphalDenn @Talon I don't think it's that catastrophic as this sounds any more. I can't say this is not happening but it's very rare. I am on @GNOME . If I get an unresponsive experience I can press alt+F2, type in orca --replace and the screen reader comes back. I can even bind this to a global keyboard shortcut.
When I am leaving my office I am often closing some 15 browser windows, some 10 terminal windows, about 5 different files open in the text editor.
Most used apps on my desktop include #Firefox #Thunderbird file manager (pcmanfm or nautilus), Gedit, VLC media player, electron based apps such as teamsforlinux, losslesscut and gnome-terminal.
Next I'm using @LibreOffice, I am also using #Emacs with #speechd-el a little and finally some other less frequently used apps.
As for the #TTS or the #audio setup I am using #RHVoice, speech-dispatcher and @PipeWire Project .
Finally with @Matt Campbell and @Lukáš Tyrychtr we do have tallented visually disabled developers dogfooding or partially dog fooding so let me finish this post by saying it really is gold era of a linux #a11y and we are looking forward for what it brings us in the future.